Endocrine Abstracts

Introduction: The relationship between hyperthyroidism and voice disorders has not been identified before. The aim of this study was to investigate the changes in the acoustic values in patients with subclinical thyrotoxicosis.Methods: In this study, acoustic voice analysis was evaluated in a total of 115 cases. Sixty of 115 individuals (18 men and 42 women) had subclinical thyrotoxicosis, aged between 18 and 65 years, and all had no history of laryngeal...

Background: Subacute thyroiditis (SAT) is a transient thyrotoxic state characterized by suppressed TSH and low uptake of iodine 123 on thyroid scanning. SAT is a self limiting, possibly viral and inflammatory thyroid disorder that is usually associated with thyroid pain and systemic symptoms. Many factors can cause SAT. Infections are considered the most common cause. Vaccines can also lead to SAT.Case report: A 46-year-old male with a history of type 1 ...

Purpose: The liver is known to be protected from steatosis under the influence of high GH/IGF-1. Cytokeratin 18 (CK18) and insulin-like growth factor binding protein 7 (IGFBP7) increase in liver steatosis and fibrosis. Whether decreasing lipid content completely protects the liver from metabolic alterations and the response of CK18 and IGFBP7 to liver changes in acromegaly is unknown.Methods: This single-center, multidisciplinary, cross-sectional study i...

Background & Aim: Adrenocortical carcinoma (ACC) is an extremely rare malignancy usually with poor outcomes, although the prognosis varies greatly depending on the initial tumor stage. Here we present clinical and outcome diversity of the patients in a single center.Methods: We retrospectively analyzed 16 patients with ACC diagnosed between 2000 and 2022. Demographical findings, hormonal status, radiological findings, ENSAT stage, weiss score and Ki6...

Introduction: CNC (Carney complex) is a rare inherited autosomal dominant syndrome characterized by prominent pigmented lesions on the skin and mucosal surfaces, cardiac and noncardiac myxomatous tumors, and multiple endocrine neoplasms. About 70% of cases have a family history, while the remaining 30% occur sporadically as a result of de novo mutation. Two genetic loci linked to CNC have been found: the CNC1 gene on chromosome 17q22-24, which encodes the regulatory subunit (R...

Section 1: Case history: 23 Year old Caribbean gentleman attended A&E with several month history of non-specific headaches, changes in memory/mood and joint pains. Since the age of 5 he had been medically treated for renal stones, He had a past medical history of sickle cell trait and was not on any regular medications. There was no significant family history apart from sickle cell disease. He had initial bloods which showed serum adjusted calcium level 3.7 mmol/l and PTH ...

Background: Immune function and responses are tightly regulated by the circadian clock system and hypothalamic-pituitary-adrenal (HPA) axis. Accumulating evidence supports that there is a strong mutual relationship between these two regulatory systems at multiple levels. Recent publications suggest that the clock system may also regulate glucocorticoid release from adrenal glands by altering the sensitivity of the adrenal cortex to adrenocorticotropic hormone (ACTH).<p cla...

Background: Circadian rhythmicity is generated by a set of genes including Period3. Changes in the expression of Period3 and other clock genes have been linked with regulation of the immune system. Period3 polymorphisms have been associated with circadian disruption and so immune system dysregulation and altered secretion of several cytokines, which can lead to inflammatory and autoimmune disorders.Aim: To investigate the influence of a polymorphism in P...

Adrenal metastasis is common (35%) among the patients with lung cancer, while less than 3% of the patients develop bilateral adrenal metastasis. Adrenal metastases are generally small and clinically asymptomatic. Adrenal insufficiency is rare despite the presence of adrenal metastasis. Lam et al. reported this ratio as 0.7%. We aimed to present a case with lung cancer and bilateral adrenal metastasis who developed adrenal insufficiency.A 63-year old male...

Adrenal lymphangioma is a rare benign tumors of the adrenal gland. Because of the increased use of imaging methods in recent times, the diagnosis is usually made incidentally. It is usually due to malformation between the lymphatic and the venous system. Those with small indiameters are generally asymptomatic and can be evacuated by needlea spiration. However, surgery is recommended for cysts over 6 cm in diameter due to risk of infection, bleeding, compression of neighboring ...